Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

DUX4 activates the first wave of zygotic gene expression in the early embryo. Mis-expression of DUX4 in skeletal muscle causes facioscapulohumeral dystrophy (FSHD), whereas expression in cancers suppresses IFNγ induction of major histocompatibility complex class I (MHC class I) and contributes to im...

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Detalles Bibliográficos
Autores principales: Spens, Amy E, Sutliff, Nicholas A, Bennett, Sean R, Campbell, Amy E, Tapscott, Stephen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195082/
https://www.ncbi.nlm.nih.gov/pubmed/37092726
http://dx.doi.org/10.7554/eLife.82057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195082/
https://www.ncbi.nlm.nih.gov/pubmed/37092726
http://dx.doi.org/10.7554/eLife.82057

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