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Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction
DUX4 activates the first wave of zygotic gene expression in the early embryo. Mis-expression of DUX4 in skeletal muscle causes facioscapulohumeral dystrophy (FSHD), whereas expression in cancers suppresses IFNγ induction of major histocompatibility complex class I (MHC class I) and contributes to im...
Autores principales: | Spens, Amy E, Sutliff, Nicholas A, Bennett, Sean R, Campbell, Amy E, Tapscott, Stephen J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195082/ https://www.ncbi.nlm.nih.gov/pubmed/37092726 http://dx.doi.org/10.7554/eLife.82057 |
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