Cargando…

UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease

BACKGROUND: Despite current improvements in systemic cancer treatment, brain metastases (BM) remain incurable, and there is an unmet clinical need for effective targeted therapies. METHODS: Here, we sought common molecular events in brain metastatic disease. RNA sequencing of thirty human BM identif...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paisana, Eunice, Cascão, Rita, Custódia, Carlos, Qin, Nan, Picard, Daniel, Pauck, David, Carvalho, Tânia, Ruivo, Pedro, Barreto, Clara, Doutel, Delfim, Cabeçadas, José, Roque, Rafael, Pimentel, José, Miguéns, José, Remke, Marc, Barata, João T, Faria, Claudia C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195208/ https://www.ncbi.nlm.nih.gov/pubmed/37215954 http://dx.doi.org/10.1093/noajnl/vdad048

Ejemplares similares

LMD-12. Ubiquitin Conjugating Enzymes promote leptomeningeal dissemination and decrease survival in patients with brain metastatic disease
por: Paisana, Eunice, et al.
Publicado: (2021)

BSCI-04 TARGETING THE PI3K-MTOR PATHWAY TO TREAT UBE2C-DRIVEN BRAIN METASTASES
por: Paisana, Eunice, et al.
Publicado: (2022)

Patient-derived models of brain metastases recapitulate human disseminated disease
por: Faria, Claudia C., et al.
Publicado: (2022)

Role of UBE2C in Brain Cancer Invasion and Dissemination
por: Domentean, Stefani, et al.
Publicado: (2023)

The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma
por: Qin, Nan, et al.
Publicado: (2023)

ABL1 and ABL2 promote medulloblastoma leptomeningeal dissemination
por: Jones, Jill K, et al.
Publicado: (2023)

EPEN-33. PHARMACOGENOMICS REVEALS SYNERGISTIC INHIBITION OF ERBB2 AND PI3K SIGNALING AS A THERAPEUTIC STRATEGY FOR EPENDYMOMA
por: Pauck, David, et al.
Publicado: (2020)

Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors
por: Blümel, Lena, et al.
Publicado: (2022)

Metastasis of renal cell carcinoma to the urethra: a rare scenario
por: Santos, Sofia Frade, et al.
Publicado: (2020)

Expression of cell type incongruent alpha-cardiac actin 1 subunit in medulloblastoma reveals a novel mechanism for cancer cell survival and control of migration
por: Suresh, Rahul, et al.
Publicado: (2021)

Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation
por: Marquardt, Viktoria, et al.
Publicado: (2023)

Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats
por: Cascão, Rita, et al.
Publicado: (2015)

Pineocytoma with diffuse dissemination to the leptomeninges
por: Gomez, Caitlin, et al.
Publicado: (2011)

Leptomeningeal disease and tumor dissemination in a murine diffuse intrinsic pontine glioma model: implications for the study of the tumor-cerebrospinal fluid-ependymal microenvironment
por: Pan, Shelei, et al.
Publicado: (2022)

Claudin-10 is a new candidate prognostic marker in metastatic high-grade serous carcinoma
por: Davidson, Ben, et al.
Publicado: (2023)

Evaluation of neurapheresis therapy in vitro: a novel approach for the treatment of leptomeningeal metastases
por: Ejikeme, Tiffany, et al.
Publicado: (2020)

Anaplastic oligodendroglioma with leptomeningeal dissemination in a French Bulldog
por: NAKAMOTO, Yuya, et al.
Publicado: (2018)

Unusual Extensive Physiologic Pigmentation of the Tongue: A Case Report
por: Neiva-Sousa, Manuel, et al.
Publicado: (2022)

Interferon-β exposure induces a fragile glioblastoma stem cell phenotype with a transcriptional profile of reduced migratory and MAPK pathway activity
por: Lohmann, Birthe, et al.
Publicado: (2020)

IMMU-07. TACEDINALINE (CI994), A CLASS I HDAC INHIBITOR, TARGETS INTRINSIC TUMOR GROWTH AND LEPTOMENINGEAL DISSEMINATION IN MYC-DRIVEN MEDULLOBLASTOMA WHILE MAKING THEM SUSCEPTIBLE TO ANTI-CD47 INDUCED MACROPHAGE PHAGOCYTOSIS VIA NF-KB-TGM2 DRIVEN TUMOR INFLAMMATION
por: Marquardt, Viktoria, et al.
Publicado: (2023)

Acute Hydrocephalus due to Secondary Leptomeningeal Dissemination of an Anaplastic Oligodendroglioma
por: Stark, Andreas M., et al.
Publicado: (2009)

Intracranial Meningioma with Leptomeningeal Dissemination : Retrospective Study with Review of the Literature
por: Park, Ki-Su, et al.
Publicado: (2015)

Glioblastoma Multiforme in the Pineal Region with Leptomeningeal Dissemination and Lumbar Metastasis
por: Matsuda, Ryosuke, et al.
Publicado: (2015)

In vivo bioluminescence imaging for leptomeningeal dissemination of medulloblastoma in mouse models
por: Choi, Seung Ah, et al.
Publicado: (2016)

Leptomeningeal Dissemination in Gall Bladder Carcinoma: Sequelae of Long-Term Survival?
por: Goyal, Shikha, et al.
Publicado: (2014)

Integrative radiogenomic analysis for genomic signatures in glioblastomas presenting leptomeningeal dissemination
por: You, Hye Jin, et al.
Publicado: (2016)

Response of Leptomeningeal Dissemination of Anaplastic Glioma to Temozolomide: Experience of Two Cases
por: Bae, Jin Woo, et al.
Publicado: (2017)

Rapid Diffuse Leptomeningeal Dissemination of an Anaplastic Pleomorphic Xanthoastrocytoma in an Adult Patient
por: Bounajem, Michael, et al.
Publicado: (2021)

RARE-47. DIFFUSE LEPTOMENINGEAL DISSEMINATED GLIONEURONAL TUMOR: CASE-SERIES
por: Sanders, Felipe Hada, et al.
Publicado: (2020)

Quantitative cerebrospinal fluid circulating tumor cells are a potential biomarker of response for proton craniospinal irradiation for leptomeningeal metastasis
por: Wijetunga, N Ari, et al.
Publicado: (2021)

Leptomeningeal dissemination of anaplastic medullary cone astrocytoma: an unexpected findings in a patient with leptomeningeal enhancement and clinical history of multiple myeloma
por: Daffini, Linda, et al.
Publicado: (2021)

2568 Pembrolizumab for patients with leptomeningeal disease from advanced solid tumors
por: Naidoo, Jarushka, et al.
Publicado: (2018)

A preclinical model of patient-derived cerebrospinal fluid circulating tumor cells for experimental therapeutics in leptomeningeal disease from melanoma
por: Law, Vincent, et al.
Publicado: (2022)

Pembrolizumab for patients with leptomeningeal metastasis from solid tumors: efficacy, safety, and cerebrospinal fluid biomarkers
por: Naidoo, Jarushka, et al.
Publicado: (2021)

Leptomeningeal Dissemination of a Low-Grade Brainstem Glioma without Local Recurrence
por: Moon, Jung-Ho, et al.
Publicado: (2012)

Primary Spinal Cord Melanoma in Thoracic Spine with Leptomeningeal Dissemination and Presenting Hydrocephalus
por: Jeong, Dong Hwan, et al.
Publicado: (2013)

Leptomeningeal disease and brain control after postoperative stereotactic radiosurgery with or without immunotherapy for resected brain metastases
por: Minniti, Giuseppe, et al.
Publicado: (2021)

Characterisation of systemic dissemination of nonreplicating adenoviral vectors from tumours in local gene delivery
por: Wang, Y, et al.
Publicado: (2005)

IMMU-19. HDAC INHIBITORS SENSITIZE MYC-AMPLIFIED MEDULLOBLASTOMA TO IMMUNOTHERAPY BY ACTIVATING THE NF-kB PATHWAYS
por: Marquardt, Viktoria, et al.
Publicado: (2020)

Ewing sarcoma dissemination and response to T-cell therapy in mice assessed by whole-body magnetic resonance imaging
por: Liebsch, L, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_gfgn4rk3f9biqgmc9c1pqncmc6