A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome

The development of curative treatments for mitochondrial diseases, which are often caused by mutations in mitochondrial DNA (mtDNA) that impair energy metabolism and other aspects of cellular homoeostasis, is hindered by an incomplete understanding of the underlying biology and a scarcity of cellula...

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Detalles Bibliográficos
Autores principales: Silva-Pinheiro, Pedro, Mutti, Christian D., Van Haute, Lindsey, Powell, Christopher A., Nash, Pavel A., Turner, Keira, Minczuk, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195678/
https://www.ncbi.nlm.nih.gov/pubmed/36470976
http://dx.doi.org/10.1038/s41551-022-00968-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195678/
https://www.ncbi.nlm.nih.gov/pubmed/36470976
http://dx.doi.org/10.1038/s41551-022-00968-1

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