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A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome
The development of curative treatments for mitochondrial diseases, which are often caused by mutations in mitochondrial DNA (mtDNA) that impair energy metabolism and other aspects of cellular homoeostasis, is hindered by an incomplete understanding of the underlying biology and a scarcity of cellula...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195678/ https://www.ncbi.nlm.nih.gov/pubmed/36470976 http://dx.doi.org/10.1038/s41551-022-00968-1 |