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Asymmetric conformations of cleaved HIV-1 envelope glycoprotein trimers in styrene-maleic acid lipid nanoparticles

During virus entry, the pretriggered human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer initially transits into a default intermediate state (DIS) that remains structurally uncharacterized. Here, we present cryo-EM structures at near-atomic resolution of two cleaved full-length...

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Detalles Bibliográficos
Autores principales: Wang, Kunyu, Zhang, Shijian, Go, Eden P., Ding, Haitao, Wang, Wei Li, Nguyen, Hanh T., Kappes, John C., Desaire, Heather, Sodroski, Joseph, Mao, Youdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195785/
https://www.ncbi.nlm.nih.gov/pubmed/37202420
http://dx.doi.org/10.1038/s42003-023-04916-w