Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions

Macrocycle peptides are promising constructs for imaging and inhibiting extracellular, and cell membrane proteins, but their use for targeting intracellular proteins is typically limited by poor cell penetration. We report the development of a cell-penetrant high-affinity peptide ligand targeted to...

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Detalles Bibliográficos
Autores principales: Nag, Arundhati, Mafi, Amirhossein, Das, Samir, Yu, Mary Beth, Alvarez-Villalonga, Belen, Kim, Soo-Kyung, Su, Yapeng, Goddard, William A., Heath, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195864/
https://www.ncbi.nlm.nih.gov/pubmed/37202473
http://dx.doi.org/10.1038/s42004-023-00890-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195864/
https://www.ncbi.nlm.nih.gov/pubmed/37202473
http://dx.doi.org/10.1038/s42004-023-00890-w

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