Cumulative effects of weakly repressive regulatory regions in the 3’ UTR maintain PD-1 expression homeostasis in mammals

PD-1 has become a common target for cancer treatment. However, the molecular regulation of PD-1 expression homeostasis remains unclear. Here we report the PD-1 3’ UTR can dramatically repress gene expression via promoting mRNA decay. Deletion of the PD-1 3’ UTR inhibits T cell activity and promotes...

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Detalles Bibliográficos
Autores principales: Lai, Xiaoqian, Li, Rong, Wang, Panpan, Li, Meng, Xiao, Chenxi, Cao, Qiang, Li, Xin, Zhao, Wenxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195876/
https://www.ncbi.nlm.nih.gov/pubmed/37202440
http://dx.doi.org/10.1038/s42003-023-04922-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195876/
https://www.ncbi.nlm.nih.gov/pubmed/37202440
http://dx.doi.org/10.1038/s42003-023-04922-y

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