Rare genetic variants underlie outlying levels of DNA methylation and gene-expression

Testing the effect of rare variants on phenotypic variation is difficult due to the need for extremely large cohorts to identify associated variants given expected effect sizes. An alternative approach is to investigate the effect of rare genetic variants on DNA methylation (DNAm) as effect sizes ar...

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Detalles Bibliográficos
Autores principales: Chundru, V Kartik, Marioni, Riccardo E, Prendergast, James G D, Lin, Tian, Beveridge, Allan J, Martin, Nicholas G, Montgomery, Grant W, Hume, David A, Deary, Ian J, Visscher, Peter M, Wray, Naomi R, McRae, Allan F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196672/
https://www.ncbi.nlm.nih.gov/pubmed/36790133
http://dx.doi.org/10.1093/hmg/ddad028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196672/
https://www.ncbi.nlm.nih.gov/pubmed/36790133
http://dx.doi.org/10.1093/hmg/ddad028

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