Mechano-covalent protection of coagulation factor VIII by von Willebrand factor

von Willebrand factor (VWF) is the protective carrier of procoagulant factor VIII (FVIII) in the shear forces of the circulation, prolonging its half-life and delivering it to the developing thrombus. Using force spectroscopy, VWF-FVIII complex formation is characterized by catch-bond behavior in wh...

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Detalles Bibliográficos
Autores principales: Butera, Diego, Wang, Haoqing Jerry, Woon, Heng-Giap, Zhao, Yunduo Charles, Ju, Lining Arnold, Hogg, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196764/
https://www.ncbi.nlm.nih.gov/pubmed/36240294
http://dx.doi.org/10.1182/bloodadvances.2022008650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196764/
https://www.ncbi.nlm.nih.gov/pubmed/36240294
http://dx.doi.org/10.1182/bloodadvances.2022008650

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