Efficient autocrine and paracrine signaling explain the osteogenic superiority of transgenic BMP-2 over rhBMP-2

Bone morphogenetic protein-2 (BMP-2) is an osteogenic protein used clinically to enhance bone healing. However, it must be applied in very high doses, causing adverse side effects and increasing costs while providing only incremental benefit. Preclinical models of bone healing using gene transfer to...

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Detalles Bibliográficos
Autores principales: Atasoy-Zeybek, Aysegul, Coenen, Michael J., Hawse, Gresin P., Logeart-Avramoglou, Delphine, Evans, Christopher H., De La Vega, Rodolfo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196773/
https://www.ncbi.nlm.nih.gov/pubmed/37214314
http://dx.doi.org/10.1016/j.omtm.2023.03.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196773/
https://www.ncbi.nlm.nih.gov/pubmed/37214314
http://dx.doi.org/10.1016/j.omtm.2023.03.017

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