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Connexin 43 dephosphorylation at serine 282 induces spontaneous arrhythmia and increases susceptibility to ischemia/reperfusion injury

BACKGROUND: Connexin 43 (Cx43), the predominant gap junction protein in hearts, is modified by specific (de)phosphorylation events under physiological and pathological states to affect myocardium function and structure. Previously we found that deficiency in Cx43 S282 phosphorylation could impair in...

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Detalles Bibliográficos
Autores principales: Wu, Lulin, Jiang, Tianhui, Fu, Zhiping, Wang, Luqi, You, Hongjie, Xue, Jingyi, Luo, Dali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196788/
https://www.ncbi.nlm.nih.gov/pubmed/37215881
http://dx.doi.org/10.1016/j.heliyon.2023.e15879