Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition

The first hematopoietic stem cells (HSCs) are formed through endothelial-to-hematopoietic transition (EHT) during embryonic development. The transcription factor GATA2 is a crucial regulator of EHT and HSC function throughout life. Because patients with GATA2 haploinsufficiency have inborn mutations...

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Detalles Bibliográficos
Autores principales: Koyunlar, Cansu, Gioacchino, Emanuele, Vadgama, Disha, de Looper, Hans, Zink, Joke, ter Borg, Mariette N. D., Hoogenboezem, Remco, Havermans, Marije, Sanders, Mathijs A., Bindels, Eric, Dzierzak, Elaine, Touw, Ivo P., de Pater, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196789/
https://www.ncbi.nlm.nih.gov/pubmed/36649572
http://dx.doi.org/10.1182/bloodadvances.2022008019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196789/
https://www.ncbi.nlm.nih.gov/pubmed/36649572
http://dx.doi.org/10.1182/bloodadvances.2022008019

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