TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia

The activation of β-catenin plays critical roles in normal stem cell function, and, when aberrantly activated, the maintenance and enhancement of cancer stemness in many solid cancers. Aberrant β-catenin activation is also observed in acute myeloid leukemia (AML), and crucially contributes to self-r...

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Detalles Bibliográficos
Autores principales: Sakoda, Teppei, Kikushige, Yoshikane, Miyamoto, Toshihiro, Irifune, Hidetoshi, Harada, Takuya, Hatakeyama, Kiwamu, Kunisaki, Yuya, Kato, Koji, Akashi, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196803/
https://www.ncbi.nlm.nih.gov/pubmed/36745103
http://dx.doi.org/10.1182/bloodadvances.2022008405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196803/
https://www.ncbi.nlm.nih.gov/pubmed/36745103
http://dx.doi.org/10.1182/bloodadvances.2022008405

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