Engineering donor lymphocytes with Fas ligand protein effectively prevents acute graft-versus-host disease

Alloreactive T-effector cells (Teffs) are the major culprit of acute graft-versus-host disease (aGVHD) associated with hematopoietic stem cell transplantation. Ex vivo nonspecific depletion of T cells from the donor graft impedes stem cell engraftment and posttransplant immune reconstitution. Teffs...

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Detalles Bibliográficos
Autores principales: Shrestha, Pradeep, Turan, Ali, Batra, Lalit, Gulen, Ayse Ece, Sun, Zhengda, Tan, Helen, Askenasy, Nadir, Shirwan, Haval, Yolcu, Esma S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196989/
https://www.ncbi.nlm.nih.gov/pubmed/36780582
http://dx.doi.org/10.1182/bloodadvances.2022008495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196989/
https://www.ncbi.nlm.nih.gov/pubmed/36780582
http://dx.doi.org/10.1182/bloodadvances.2022008495

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