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Engineering donor lymphocytes with Fas ligand protein effectively prevents acute graft-versus-host disease

Alloreactive T-effector cells (Teffs) are the major culprit of acute graft-versus-host disease (aGVHD) associated with hematopoietic stem cell transplantation. Ex vivo nonspecific depletion of T cells from the donor graft impedes stem cell engraftment and posttransplant immune reconstitution. Teffs...

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Detalles Bibliográficos
Autores principales:	Shrestha, Pradeep, Turan, Ali, Batra, Lalit, Gulen, Ayse Ece, Sun, Zhengda, Tan, Helen, Askenasy, Nadir, Shirwan, Haval, Yolcu, Esma S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196989/ https://www.ncbi.nlm.nih.gov/pubmed/36780582 http://dx.doi.org/10.1182/bloodadvances.2022008495

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