Novel oral SPT inhibitor CH5169356 inhibits hepatic stellate cell activation and ameliorates hepatic fibrosis in mouse models of non‐alcoholic steatohepatitis (NASH)

Ceramide is a central molecule of sphingolipid metabolism and is involved in the development of non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH). It has already been reported that the inhibition of serine palmitoyltransferase (SPT), the rate‐limiting enzyme in the s...

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Detalles Bibliográficos
Autores principales: Hada, Natsuko, Katsume, Asao, Kenichi, Kawasaki, Endo, Chihiro, Horiba, Naoshi, Sudoh, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197225/
https://www.ncbi.nlm.nih.gov/pubmed/37204099
http://dx.doi.org/10.1002/prp2.1094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197225/
https://www.ncbi.nlm.nih.gov/pubmed/37204099
http://dx.doi.org/10.1002/prp2.1094

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