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Interplay of macromolecular interactions during assembly of human DNA polymerase δ holoenzymes and initiation of DNA synthesis

In humans, DNA polymerase δ (Pol δ) holoenzymes, comprised of Pol δ and the processivity sliding clamp, proliferating cell nuclear antigen (PCNA), carry out DNA synthesis during lagging strand DNA replication, initiation of leading strand DNA replication, and the major DNA damage repair and toleranc...

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Detalles Bibliográficos
Autores principales: Norris, Jessica L., Rogers, Lindsey O., Pytko, Kara G., Dannenberg, Rachel L., Perreault, Samuel, Kaushik, Vikas, Kuppa, Sahiti, Antony, Edwin, Hedglin, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197535/
https://www.ncbi.nlm.nih.gov/pubmed/37215012
http://dx.doi.org/10.1101/2023.05.09.539896