Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers

INTRODUCTION: Neuronal nuclei are normally smoothly surfaced. In Alzheimer’s disease (AD) and other tauopathies, though, they often develop invaginations. We investigated mechanisms and functional consequences of neuronal nuclear invagination in tauopathies. METHODS: Nuclear invagination was assayed...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Xuehan, Eastman, Guillermo, Shi, Yu, Saibaba, Subhi, Oliveira, Ana K., Lukens, John R., Norambuena, Andrés, Mandell, James W., Bloom, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197541/
https://www.ncbi.nlm.nih.gov/pubmed/37214909
http://dx.doi.org/10.1101/2023.05.08.539873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197541/
https://www.ncbi.nlm.nih.gov/pubmed/37214909
http://dx.doi.org/10.1101/2023.05.08.539873

Ejemplares similares