Molecular features driving condensate formation and gene expression by the BRD4-NUT fusion oncoprotein are overlapping but distinct

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Aberrant formation of biomolecular condensates has been proposed to play a role in several cancers. The oncogenic fusion protein BRD4-NUT forms condensates and drives changes in gene expression in Nut Carcinoma (NC). Here we sought to understand the molecular elements of BRD4-NUT and its associated...

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Detalles Bibliográficos
Autores principales: Kosno, Martyna, Currie, Simon L., Kumar, Ashwani, Xing, Chao, Rosen, Michael K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197624/
https://www.ncbi.nlm.nih.gov/pubmed/37214845
http://dx.doi.org/10.1101/2023.05.11.540414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197624/
https://www.ncbi.nlm.nih.gov/pubmed/37214845
http://dx.doi.org/10.1101/2023.05.11.540414

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