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Generalized fear following acute stress is caused by change in co-transmitter identity of serotonergic neurons

Overgeneralization of fear to harmless situations is a core feature of anxiety disorders resulting from acute stress, yet the mechanisms by which fear becomes generalized are poorly understood. Here we show that generalized fear in mice in response to footshock results from a transmitter switch from...

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Detalles Bibliográficos
Autores principales: Li, Hui-quan, Jiang, Wuji, Ling, Lily, Gupta, Vaidehi, Chen, Cong, Pratelli, Marta, Godavarthi, Swetha K., Spitzer, Nicholas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197626/
https://www.ncbi.nlm.nih.gov/pubmed/37214936
http://dx.doi.org/10.1101/2023.05.10.540268