De novo distillation of thermodynamic affinity from deep learning regulatory sequence models of in vivo protein-DNA binding

Transcription factors (TF) are proteins that bind DNA in a sequence-specific manner to regulate gene transcription. Despite their unique intrinsic sequence preferences, in vivo genomic occupancy profiles of TFs differ across cellular contexts. Hence, deciphering the sequence determinants of TF bindi...

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Detalles Bibliográficos
Autores principales: Alexandari, Amr M., Horton, Connor A., Shrikumar, Avanti, Shah, Nilay, Li, Eileen, Weilert, Melanie, Pufall, Miles A., Zeitlinger, Julia, Fordyce, Polly M., Kundaje, Anshul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197627/
https://www.ncbi.nlm.nih.gov/pubmed/37214836
http://dx.doi.org/10.1101/2023.05.11.540401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197627/
https://www.ncbi.nlm.nih.gov/pubmed/37214836
http://dx.doi.org/10.1101/2023.05.11.540401

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