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De novo distillation of thermodynamic affinity from deep learning regulatory sequence models of in vivo protein-DNA binding
Transcription factors (TF) are proteins that bind DNA in a sequence-specific manner to regulate gene transcription. Despite their unique intrinsic sequence preferences, in vivo genomic occupancy profiles of TFs differ across cellular contexts. Hence, deciphering the sequence determinants of TF bindi...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197627/ https://www.ncbi.nlm.nih.gov/pubmed/37214836 http://dx.doi.org/10.1101/2023.05.11.540401 |