Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s disease

Maternal choline supplementation (MCS) improves cognition in Alzheimer’s disease (AD) models. However, effects of MCS on neuronal hyperexcitability in AD are unknown. We investigated effects of MCS in a well-established mouse model of AD with hyperexcitability, the Tg2576 mouse. The most common type...

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Detalles Bibliográficos
Autores principales: Chartampila, Elissavet, Elayouby, Karim S., Leary, Paige, LaFrancois, John J., Alcantara-Gonzalez, David, Jain, Swati, Gerencer, Kasey, Botterill, Justin J., Ginsberg, Stephen D., Scharfman, Helen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197642/
https://www.ncbi.nlm.nih.gov/pubmed/37214805
http://dx.doi.org/10.1101/2023.05.12.540428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197642/
https://www.ncbi.nlm.nih.gov/pubmed/37214805
http://dx.doi.org/10.1101/2023.05.12.540428

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