SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis

PURPOSE: Osteosarcoma (OS) is an aggressive bone malignancy with a poor prognosis. One putative proto-oncogene in OS is SKP2, encoding a substrate recognition factor of the SCF E3 ubiquitin ligase. We previously demonstrated that SKP2 knockout in murine OS improved survival and delayed tumorigenesis...

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Detalles Bibliográficos
Autores principales: Ferrena, Alexander, Wang, Jichuan, Zhang, Ranxin, Karadal-Ferrena, Burcu, Al-Hardan, Waleed, Singh, Swapnil, Borjihan, Hasibagan, Schwartz, Edward, Zhao, Hongling, Yang, Rui, Geller, David, Hoang, Bang, Zheng, Deyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197654/
https://www.ncbi.nlm.nih.gov/pubmed/37214958
http://dx.doi.org/10.1101/2023.05.09.540053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197654/
https://www.ncbi.nlm.nih.gov/pubmed/37214958
http://dx.doi.org/10.1101/2023.05.09.540053

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