Polygenic risk affects the penetrance of monogenic kidney disease

BACKGROUND: Chronic kidney disease (CKD) is a genetically complex disease determined by an interplay of monogenic, polygenic, and environmental risks. Most forms of monogenic kidney diseases have incomplete penetrance and variable expressivity. It is presently unknown if some of the variability in p...

Descripción completa

Detalles Bibliográficos
Autores principales: Khan, Atlas, Shang, Ning, Nestor, Jordan G., Weng, Chunhua, Hripcsak, George, Harris, Peter C., Gharavi, Ali G., Kiryluk, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197721/
https://www.ncbi.nlm.nih.gov/pubmed/37214819
http://dx.doi.org/10.1101/2023.05.07.23289614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197721/
https://www.ncbi.nlm.nih.gov/pubmed/37214819
http://dx.doi.org/10.1101/2023.05.07.23289614

Ejemplares similares