Dual targeting ovarian cancer by Muc16 CAR-T cells secreting a bispecific T cell engager antibody for an intracellular tumor antigen WT1

Epithelial ovarian cancer is the most lethal of gynecological cancers. The therapeutic efficacy of chimeric antigen receptor (CAR) T cell directed against single antigens is limited by the heterogeneous target antigen expression in epithelial ovarian tumors. To overcome this limitation, we describe...

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Detalles Bibliográficos
Autores principales: Mun, Sung Soo, Peraro, Leila, Meyerberg, Jeremy, Korontsvit, Tatyana, Malviya, Manish, Gardner, Thomas, Kyi, Chrisann, O’Cearbhaill, Roisin E., Liu, Cheng, Dao, Tao, Scheinberg, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197740/
https://www.ncbi.nlm.nih.gov/pubmed/37214945
http://dx.doi.org/10.21203/rs.3.rs-2887299/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197740/
https://www.ncbi.nlm.nih.gov/pubmed/37214945
http://dx.doi.org/10.21203/rs.3.rs-2887299/v1

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