Longitudinal modeling of human neuronal aging identifies RCAN1-TFEB pathway contributing to neurodegeneration of Huntington’s disease

Aging is a common risk factor in neurodegenerative disorders and the ability to investigate aging of neurons in an isogenic background would facilitate discovering the interplay between neuronal aging and onset of neurodegeneration. Here, we perform direct neuronal reprogramming of longitudinally co...

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Detalles Bibliográficos
Autores principales: Lee, Seong Won, Oh, Young Mi, Victor, Matheus B., Strunilin, Ilya, Chen, Shawei, Dahiya, Sonika, Dolle, Roland E., Pak, Stephen C., Silverman, Gary A., Perlmutter, David H., Yoo, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197783/
https://www.ncbi.nlm.nih.gov/pubmed/37214956
http://dx.doi.org/10.21203/rs.3.rs-2815300/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197783/
https://www.ncbi.nlm.nih.gov/pubmed/37214956
http://dx.doi.org/10.21203/rs.3.rs-2815300/v1

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