Cargando…

Longitudinal modeling of human neuronal aging identifies RCAN1-TFEB pathway contributing to neurodegeneration of Huntington’s disease

Aging is a common risk factor in neurodegenerative disorders and the ability to investigate aging of neurons in an isogenic background would facilitate discovering the interplay between neuronal aging and onset of neurodegeneration. Here, we perform direct neuronal reprogramming of longitudinally co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Seong Won, Oh, Young Mi, Victor, Matheus B., Strunilin, Ilya, Chen, Shawei, Dahiya, Sonika, Dolle, Roland E., Pak, Stephen C., Silverman, Gary A., Perlmutter, David H., Yoo, Andrew S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197783/ https://www.ncbi.nlm.nih.gov/pubmed/37214956 http://dx.doi.org/10.21203/rs.3.rs-2815300/v1

Ejemplares similares

Spatiotemporal expression of RCAN1 and its isoform RCAN1-4 in the mouse hippocampus after pilocarpine-induced status epilepticus
por: Cho, Kyung-Ok, et al.
Publicado: (2020)

MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer’s Disease
por: Chun, Yoon Sun, et al.
Publicado: (2022)

RCANs regulate the convergent roles of NFATc1 in bone homeostasis
por: Kim, Jung Ha, et al.
Publicado: (2016)

Histone Deacetylase 3 Promotes RCAN1 Stability and Nuclear Translocation
por: Han, Kyung Ah, et al.
Publicado: (2014)

A major role for RCAN1 in atherosclerosis progression
por: Méndez-Barbero, Nerea, et al.
Publicado: (2013)

Glycation potentiates neurodegeneration in models of Huntington’s disease
por: Vicente Miranda, Hugo, et al.
Publicado: (2016)

RCAN1C is differentially expressed in T helper cell subsets
por: Sieber, M, et al.
Publicado: (2009)

RCAN1 in the inverse association between Alzheimer’s disease and cancer
por: Fu, Qiang, et al.
Publicado: (2017)

Regulator of Calcineurin (RCAN): Beyond Down Syndrome Critical Region
por: Lee, Sun-Kyung, et al.
Publicado: (2020)

Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
por: Margulis, Julia, et al.
Publicado: (2014)

A splicing variant of TFEB negatively regulates the TFEB-autophagy pathway
por: Park, Jee-Yun, et al.
Publicado: (2021)

Complexity of Bidirectional Transcription and Alternative Splicing at Human RCAN3 Locus
por: Facchin, Federica, et al.
Publicado: (2011)

The Vertebrate RCAN Gene Family: Novel Insights into Evolution, Structure and Regulation
por: Serrano-Candelas, Eva, et al.
Publicado: (2014)

RCAN1 Overexpression Exacerbates Calcium Overloading-Induced Neuronal Apoptosis
por: Sun, Xiulian, et al.
Publicado: (2014)

Rcan2 and estradiol independently regulate body weight in female mice
por: Ding, Ling-Cui, et al.
Publicado: (2017)

RCAN1-mediated calcineurin inhibition as a target for cancer therapy
por: Lao, Mengyi, et al.
Publicado: (2022)

Ku70 Alleviates Neurodegeneration in Drosophila Models of Huntington's Disease
por: Tamura, Takuya, et al.
Publicado: (2011)

Ribosome traffic jam in neurodegeneration: decoding hurdles in Huntington disease
por: Subramaniam, Srinivasa
Publicado: (2021)

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease
por: Ju, Tz-Chuen, et al.
Publicado: (2011)

Novel Identified Circular Transcript of RCAN2, circ-RCAN2, Shows Deviated Expression Pattern in Pig Reperfused Infarcted Myocardium and Hypoxic Porcine Cardiac Progenitor Cells In Vitro
por: Mester-Tonczar, Julia, et al.
Publicado: (2021)

Behavioral Characterization of a Mouse Model Overexpressing DSCR1/ RCAN1
por: Dierssen, Mara, et al.
Publicado: (2011)

RCAN1 Is an Important Mediator of Glucocorticoid-Induced Apoptosis in Human Leukemic Cells
por: Nagao, Kazuaki, et al.
Publicado: (2012)

The RCAN1 inhibits NF-κB and suppresses lymphoma growth in mice
por: Liu, C, et al.
Publicado: (2015)

The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin
por: Li, Yang, et al.
Publicado: (2020)

RCAN1 in cardiovascular diseases: molecular mechanisms and a potential therapeutic target
por: Wang, Shuai, et al.
Publicado: (2020)

Correction: Ku70 Alleviates Neurodegeneration in Drosophila Models of Huntington's Disease
por: Tamura, Takuya, et al.
Publicado: (2012)

Prodromal Huntington Disease as a Model for Functional Compensation of Early Neurodegeneration
por: Malejko, Kathrin, et al.
Publicado: (2014)

Striatal Neurodegeneration that Mimics Huntington’s Disease Modifies GABA-induced Currents
por: Flores-Hernández, Jorge, et al.
Publicado: (2018)

Transgenic minipig model of Huntington's disease exhibiting gradually progressing neurodegeneration
por: Ardan, Taras, et al.
Publicado: (2019)

Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease
por: Liu, Chunyue, et al.
Publicado: (2022)

RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells
por: Peiris, Heshan, et al.
Publicado: (2014)

The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development
por: Torac, E, et al.
Publicado: (2014)

RCAN-11R peptide provides immunosuppression for fully mismatched islet allografts in mice
por: Noguchi, Hirofumi, et al.
Publicado: (2017)

NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network
por: Mammarella, Eleonora, et al.
Publicado: (2021)

A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration
por: De Luca, Gabriele, et al.
Publicado: (2008)

Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models
por: Smalley, Joshua L., et al.
Publicado: (2015)

VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease
por: Guo, Xing, et al.
Publicado: (2016)

Transposable element activation promotes neurodegeneration in a Drosophila model of Huntington's disease
por: Casale, Assunta Maria, et al.
Publicado: (2021)

Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration
por: Estevez-Fraga, Carlos, et al.
Publicado: (2023)

Surviving starvation simply without TFEB
por: Soukas, Alexander A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_otlsb7kt6j5p82igbmphrhm9u9