Methionyl-tRNA formyltransferase utilizes 10-formyldihydrofolate as an alternative substrate and impacts antifolate drug action

Methionyl-tRNA formyltransferase (Fmt)-mediated formylation of Met-tRNA(fMet) to fMet-tRNA(fMet) is crucial for efficient initiation of translation in bacteria and the eukaryotic organelles. Folate dehydrogenase-cyclohydrolase (FolD), a bifunctional enzyme, carries out conversion of 5,10-methylene t...

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Detalles Bibliográficos
Autores principales: Sah, Shivjee, Varshney, Umesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2023
Materias:
Microbial Physiology, Biochemistry and Metabolism (formerly Physiology and Metabolism)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197868/
https://www.ncbi.nlm.nih.gov/pubmed/36745551
http://dx.doi.org/10.1099/mic.0.001297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197868/
https://www.ncbi.nlm.nih.gov/pubmed/36745551
http://dx.doi.org/10.1099/mic.0.001297

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