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Methionyl-tRNA formyltransferase utilizes 10-formyldihydrofolate as an alternative substrate and impacts antifolate drug action

Methionyl-tRNA formyltransferase (Fmt)-mediated formylation of Met-tRNA(fMet) to fMet-tRNA(fMet) is crucial for efficient initiation of translation in bacteria and the eukaryotic organelles. Folate dehydrogenase-cyclohydrolase (FolD), a bifunctional enzyme, carries out conversion of 5,10-methylene t...

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Detalles Bibliográficos
Autores principales:	Sah, Shivjee, Varshney, Umesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Microbiology Society 2023
Materias:	Microbial Physiology, Biochemistry and Metabolism (formerly Physiology and Metabolism)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197868/ https://www.ncbi.nlm.nih.gov/pubmed/36745551 http://dx.doi.org/10.1099/mic.0.001297

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