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The deubiquitinase UCHL1 negatively controls osteoclastogenesis by regulating TAZ/NFATC1 signalling

The ubiquitin‒proteasome system (UPS) plays a key role in maintaining protein homeostasis and bone remodelling. However, the role of deubiquitinating enzymes (DUBs) in bone resorption is still not well defined. Here, we identified the deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) as a nega...

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Detalles Bibliográficos
Autores principales: Feng, Zhenhua, Tao, Siyue, Huang, Zhaobo, Zheng, Bingjie, Kong, Xiangxi, Xiang, Yufeng, Zhang, Qibin, Song, Haixin, Xu, Zhikun, Wei, Xiaoan, Zhao, Fengdong, Chen, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10197889/
https://www.ncbi.nlm.nih.gov/pubmed/37215988
http://dx.doi.org/10.7150/ijbs.82152