Recombinant Klotho attenuates IFNγ receptor signaling and SAMHD1 expression through blocking NF-κB translocation in glomerular mesangial cells

Interferon gamma (IFNγ) is a cytokine implicated in the pathogenesis of autoimmune diseases. SAM and HD domain-containing protein 1 (SAMHD1) is an IFNγ-inducible protein that modulates cellular dNTP levels. Mutations in the human SAMHD1 gene cause Aicardi-Goutières (AG) syndrome, an autoimmune disea...

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Detalles Bibliográficos
Autores principales: Tsai, Kuen-Daw, Lee, Yi-Chao, Chen, Bo-Yu, Wu, Li-Syuan, Liang, Shan-Yuan, Liu, Ming-Yuan, Hung, Yu-Wen, Hsu, Hui-Ling, Chen, Pei-Qi, Shieh, Jia-Ching, Lee, Yi-Ju, Lin, Ting-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198147/
https://www.ncbi.nlm.nih.gov/pubmed/37213666
http://dx.doi.org/10.7150/ijms.78279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198147/
https://www.ncbi.nlm.nih.gov/pubmed/37213666
http://dx.doi.org/10.7150/ijms.78279

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