CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation

Cyclin-dependent kinase 12 (CDK12) interacts with cyclin K to form a functional nuclear kinase that promotes processive transcription elongation through phosphorylation of the C-terminal domain of RNA polymerase II (Pol II). To gain a comprehensive understanding of CDK12's cellular function, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Min, Yin, Zhinang, Wang, Honghong, Lei, Lingyu, Li, Conghui, Cui, Yali, Dai, Rong, Yang, Peiyuan, Xiang, Ying, Li, Qiuzi, Lv, Junhui, Hu, Zhuang, Chen, Min, Zhou, Hai-Bing, Fang, Pingping, Xiao, Ruijing, Liang, Kaiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198629/
https://www.ncbi.nlm.nih.gov/pubmed/37205756
http://dx.doi.org/10.1126/sciadv.adf8698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198629/
https://www.ncbi.nlm.nih.gov/pubmed/37205756
http://dx.doi.org/10.1126/sciadv.adf8698

Ejemplares similares