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CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation

Cyclin-dependent kinase 12 (CDK12) interacts with cyclin K to form a functional nuclear kinase that promotes processive transcription elongation through phosphorylation of the C-terminal domain of RNA polymerase II (Pol II). To gain a comprehensive understanding of CDK12's cellular function, we...

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Detalles Bibliográficos
Autores principales:	Qiu, Min, Yin, Zhinang, Wang, Honghong, Lei, Lingyu, Li, Conghui, Cui, Yali, Dai, Rong, Yang, Peiyuan, Xiang, Ying, Li, Qiuzi, Lv, Junhui, Hu, Zhuang, Chen, Min, Zhou, Hai-Bing, Fang, Pingping, Xiao, Ruijing, Liang, Kaiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198629/ https://www.ncbi.nlm.nih.gov/pubmed/37205756 http://dx.doi.org/10.1126/sciadv.adf8698

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