Molecular evolution of Keap1 was essential for adaptation of vertebrates to terrestrial life

Reactive oxygen species (ROS) posed a risk for the transition of vertebrates from aquatic to terrestrial life. How ancestral organisms adapted to such ROS exposure has remained a mystery. Here, we show that attenuation of the activity of the ubiquitin ligase CRL3Keap1 for the transcription factor Nr...

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Detalles Bibliográficos
Autores principales: Yumimoto, Kanae, Sugiyama, Shigeaki, Motomura, Saori, Takahashi, Daisuke, Nakayama, Keiichi I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198636/
https://www.ncbi.nlm.nih.gov/pubmed/37205751
http://dx.doi.org/10.1126/sciadv.adg2379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198636/
https://www.ncbi.nlm.nih.gov/pubmed/37205751
http://dx.doi.org/10.1126/sciadv.adg2379

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