Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic male mice

Skeletal fragility is associated with type 2 diabetes mellitus (T2D), but the underlying mechanism is not well understood. Here, in a mouse model for youth-onset T2D, we show that both trabecular and cortical bone mass is reduced due to diminished osteoblast activity. Stable isotope tracing in vivo...

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Detalles Bibliográficos
Autores principales: Song, Fangfang, Lee, Won Dong, Marmo, Tyler, Ji, Xing, Song, Chao, Liao, Xueyang, Seeley, Rebecca, Yao, Lutian, Liu, Haoran, Long, Fanxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198725/
https://www.ncbi.nlm.nih.gov/pubmed/37144869
http://dx.doi.org/10.7554/eLife.85714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198725/
https://www.ncbi.nlm.nih.gov/pubmed/37144869
http://dx.doi.org/10.7554/eLife.85714

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