Cargando…

Different effects of NK cells and NK-derived soluble factors on cell lines derived from primary or metastatic pancreatic cancers

Natural killer (NK) cells are cytotoxic lymphoid cells that play a key role in defenses against tumors. However, their function may be severely impaired in patients with pancreatic adenocarcinoma (PA). Indeed, PA cells release soluble factors, thereby generating an immunosuppressive environment that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fiore, Piera Filomena, Di Pace, Anna Laura, Conti, Libenzio Adrian, Tumino, Nicola, Besi, Francesca, Scaglione, Silvia, Munari, Enrico, Moretta, Lorenzo, Vacca, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198856/ https://www.ncbi.nlm.nih.gov/pubmed/36451048 http://dx.doi.org/10.1007/s00262-022-03340-z

Ejemplares similares

Characterization of Human NK Cell-Derived Exosomes: Role of DNAM1 Receptor in Exosome-Mediated Cytotoxicity against Tumor
por: Di Pace, Anna Laura, et al.
Publicado: (2020)

Wilms’ Tumor Primary Cells Display Potent Immunoregulatory Properties on NK Cells and Macrophages
por: Fiore, Piera Filomena, et al.
Publicado: (2021)

Interaction Between MDSC and NK Cells in Solid and Hematological Malignancies: Impact on HSCT
por: Tumino, Nicola, et al.
Publicado: (2021)

Exploiting Human NK Cells in Tumor Therapy
por: Vacca, Paola, et al.
Publicado: (2020)

The tumor microenvironment drives NK cell metabolic dysfunction leading to impaired antitumor activity
por: Tumino, Nicola, et al.
Publicado: (2022)

PD-1 in human NK cells: evidence of cytoplasmic mRNA and protein expression
por: Mariotti, Francesca R., et al.
Publicado: (2018)

Analysis of the mechanisms regulating soluble PD-1 production and function in human NK cells
por: Mariotti, Francesca Romana, et al.
Publicado: (2023)

MicroRNA analysis of Natural Killer cell-derived exosomes: the microRNA let-7b-5p is enriched in exosomes and participates in their anti-tumor effects against pancreatic cancer cells
por: Di Pace, Anna Laura, et al.
Publicado: (2023)

Pediatric Tumors-Mediated Inhibitory Effect on NK Cells: The Case of Neuroblastoma and Wilms’ Tumors
por: Pelosi, Andrea, et al.
Publicado: (2021)

PMN-MDSC are a new target to rescue graft-versus-leukemia activity of NK cells in haplo-HSC transplantation
por: Tumino, Nicola, et al.
Publicado: (2019)

Polymorphonuclear Myeloid-Derived Suppressor Cells Are Abundant in Peripheral Blood of Cancer Patients and Suppress Natural Killer Cell Anti-Tumor Activity
por: Tumino, Nicola, et al.
Publicado: (2022)

Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer
por: Sivori, Simona, et al.
Publicado: (2020)

NK Cells and PMN-MDSCs in the Graft From G-CSF Mobilized Haploidentical Donors Display Distinct Gene Expression Profiles From Those of the Non-Mobilized Counterpart
por: Pelosi, Andrea, et al.
Publicado: (2021)

Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing
por: Ingegnere, Tiziano, et al.
Publicado: (2019)

Presence of innate lymphoid cells in pleural effusions of primary and metastatic tumors: Functional analysis and expression of PD‐1 receptor
por: Tumino, Nicola, et al.
Publicado: (2019)

Helper Innate Lymphoid Cells in Allogenic Hematopoietic Stem Cell Transplantation and Graft Versus Host Disease
por: Quatrini, Linda, et al.
Publicado: (2020)

Heterogeneity of NK Cells and Other Innate Lymphoid Cells in Human and Murine Decidua
por: Vacca, Paola, et al.
Publicado: (2019)

NK Cells and Other Innate Lymphoid Cells in Hematopoietic Stem Cell Transplantation
por: Vacca, Paola, et al.
Publicado: (2016)

Melanoma immunoediting by NK cells
por: Balsamo, Mirna, et al.
Publicado: (2012)

How melanoma cells inactivate NK cells
por: Pietra, Gabriella, et al.
Publicado: (2012)

NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?
por: Vacca, Paola, et al.
Publicado: (2013)

Human NK Cells: From Surface Receptors to the Therapy of Leukemias and Solid Tumors
por: Moretta, Lorenzo, et al.
Publicado: (2014)

Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation
por: Pende, Daniela, et al.
Publicado: (2019)

The Immune Checkpoint PD-1 in Natural Killer Cells: Expression, Function and Targeting in Tumour Immunotherapy
por: Quatrini, Linda, et al.
Publicado: (2020)

The Latest Approach of Immunotherapy with Endosomal TLR Agonists Improving NK Cell Function: An Overview
por: Veneziani, Irene, et al.
Publicado: (2022)

Helper Innate Lymphoid Cells in Human Tumors: A Double-Edged Sword?
por: Tumino, Nicola, et al.
Publicado: (2020)

Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells
por: Ferlazzo, Guido, et al.
Publicado: (2002)

Susceptibility of Human Melanoma Cells to Autologous Natural Killer (NK) Cell Killing: HLA-Related Effector Mechanisms and Role of Unlicensed NK Cells
por: Carrega, Paolo, et al.
Publicado: (2009)

NK Cell Precursors in Human Bone Marrow in Health and Inflammation
por: Bozzano, Federica, et al.
Publicado: (2019)

NK Cell-Based Immunotherapy for Hematological Malignancies
por: Sivori, Simona, et al.
Publicado: (2019)

Stromal Cells from Human Decidua Exert a Strong Inhibitory Effect on NK Cell Function and Dendritic Cell Differentiation
por: Croxatto, Daniele, et al.
Publicado: (2014)

Human NK Cell Subsets Redistribution in Pathological Conditions: A Role for CCR7 Receptor
por: Pesce, Silvia, et al.
Publicado: (2016)

NK cell-derived IL-10 is critical for DC-NK cell dialogue at the maternal-fetal interface
por: Blois, Sandra M., et al.
Publicado: (2017)

Unique Eomes(+) NK Cell Subsets Are Present in Uterus and Decidua During Early Pregnancy
por: Montaldo, Elisa, et al.
Publicado: (2016)

Activating KIRs and NKG2C in Viral Infections: Toward NK Cell Memory?
por: Della Chiesa, Mariella, et al.
Publicado: (2015)

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration
por: Parodi, Monica, et al.
Publicado: (2018)

Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastoma
por: Tumino, Nicola, et al.
Publicado: (2021)

Human NK Cells and Herpesviruses: Mechanisms of Recognition, Response and Adaptation
por: Della Chiesa, Mariella, et al.
Publicado: (2019)

Human NK cells, their receptors and function [Image: see text]
por: Quatrini, Linda, et al.
Publicado: (2021)

Emerging NK cell therapies for cancer and the promise of next generation engineering of iPSC-derived NK cells
por: Maddineni, Sainiteesh, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4anqdujrp349k17jcne6rt134l