Radiotherapy enhances CXCR3(high)CD8(+) T cell activation through inducing IFNγ-mediated CXCL10 and ICAM-1 expression in lung cancer cells

Radiotherapy (RT) not only damages tumors but also induces interferon (IFN) expression in tumors. IFNs mediate PD-L1 to exhaust CD8(+) T cells, but which also directly impact tumor cells and potentially activate anti-tumor immune surveillance. Little is known about the contradictory mechanism of IFN...

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Detalles Bibliográficos
Autores principales: Wang, Chih-Liang, Ho, Ai-Sheng, Chang, Chun-Chao, Sie, Zong-Lin, Peng, Cheng-Liang, Chang, Jungshan, Cheng, Chun-Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198930/
https://www.ncbi.nlm.nih.gov/pubmed/36688994
http://dx.doi.org/10.1007/s00262-023-03379-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198930/
https://www.ncbi.nlm.nih.gov/pubmed/36688994
http://dx.doi.org/10.1007/s00262-023-03379-6

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