Prosaposin PS18 reduces dopaminergic neurodegeneration in a 6-hydroxydopamine rat model of Parkinson’s disease

Saposin and its precursor prosaposin are endogenous proteins with neurotrophic and anti-apoptotic properties. Prosaposin or its analog prosaposin-derived 18-mer peptide (PS18) reduced neuronal damage in hippocampus and apoptosis in stroke brain. Its role in Parkinson’s disease (PD) has not been well...

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Detalles Bibliográficos
Autores principales: Wu, Kuo-Jen, Hung, Tsai-Wei, Wang, Yu-Syuan, Chen, Yun-Hsiang, Bae, Eun-Kyung, Yu, Seong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199088/
https://www.ncbi.nlm.nih.gov/pubmed/37208379
http://dx.doi.org/10.1038/s41598-023-35274-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199088/
https://www.ncbi.nlm.nih.gov/pubmed/37208379
http://dx.doi.org/10.1038/s41598-023-35274-6

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