ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer

Targetable drivers governing 5-fluorouracil and cisplatin (5FU + CDDP) resistance remain elusive due to the paucity of physiologically and therapeutically relevant models. Here, we establish 5FU + CDDP resistant intestinal subtype GC patient-derived organoid lines. JAK/STAT signaling and its downstr...

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Detalles Bibliográficos
Autores principales: Wong, Tin-Lok, Loh, Jia-Jian, Lu, Shixun, Yan, Helen H. N., Siu, Hoi Cheong, Xi, Ren, Chan, Dessy, Kam, Max J. F., Zhou, Lei, Tong, Man, Copland, John A., Chen, Leilei, Yun, Jing-Ping, Leung, Suet Yi, Ma, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199093/
https://www.ncbi.nlm.nih.gov/pubmed/37208334
http://dx.doi.org/10.1038/s41467-023-38581-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199093/
https://www.ncbi.nlm.nih.gov/pubmed/37208334
http://dx.doi.org/10.1038/s41467-023-38581-8

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