Molecular mechanism of hyperactivation conferred by a truncation of TRPA1

A drastic TRPA1 mutant (R919*) identified in CRAMPT syndrome patients has not been mechanistically characterized. Here, we show that the R919* mutant confers hyperactivity when co-expressed with wild type (WT) TRPA1. Using functional and biochemical assays, we reveal that the R919* mutant co-assembl...

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Detalles Bibliográficos
Autores principales: Bali, Avnika, Schaefer, Samantha P., Trier, Isabelle, Zhang, Alice L., Kabeche, Lilian, Paulsen, Candice E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199097/
https://www.ncbi.nlm.nih.gov/pubmed/37208332
http://dx.doi.org/10.1038/s41467-023-38542-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199097/
https://www.ncbi.nlm.nih.gov/pubmed/37208332
http://dx.doi.org/10.1038/s41467-023-38542-1

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