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Molecular mechanism of hyperactivation conferred by a truncation of TRPA1
A drastic TRPA1 mutant (R919*) identified in CRAMPT syndrome patients has not been mechanistically characterized. Here, we show that the R919* mutant confers hyperactivity when co-expressed with wild type (WT) TRPA1. Using functional and biochemical assays, we reveal that the R919* mutant co-assembl...
Autores principales: | Bali, Avnika, Schaefer, Samantha P., Trier, Isabelle, Zhang, Alice L., Kabeche, Lilian, Paulsen, Candice E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199097/ https://www.ncbi.nlm.nih.gov/pubmed/37208332 http://dx.doi.org/10.1038/s41467-023-38542-1 |
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