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MicroRNA-122-functionalized DNA tetrahedron stimulate hepatic differentiation of human mesenchymal stem cells for acute liver failure therapy

As the most abundant liver-specific microRNA, microRNA-122 (miR122) played a crucial role in the differentiation of stem cells into hepatocytes. However, highly efficient miR122 delivery still confronts challenges including poor cellular uptake and easy biodegradation. Herein, we for the first time...

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Detalles Bibliográficos
Autores principales: Wei, Hongyan, Li, Fenfang, Xue, Tiantian, Wang, Haixia, Ju, Enguo, Li, Mingqiang, Tao, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199164/
https://www.ncbi.nlm.nih.gov/pubmed/37214257
http://dx.doi.org/10.1016/j.bioactmat.2023.04.024