Cargando…
Domain-specific modulatory effects of phosphomimetic substitutions on liquid-liquid phase separation of tau protein
Aggregation of tau is one of the major pathogenic events in Alzheimer’s disease and several other neurodegenerative disorders. Recent reports demonstrated that tau can condense into liquid droplets that undergo time-dependent transition to a solid-like state, suggesting that liquid condensates may b...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199205/ https://www.ncbi.nlm.nih.gov/pubmed/37075845 http://dx.doi.org/10.1016/j.jbc.2023.104722 |