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Neutral theory: applicability and neutrality of clinical study endpoints where a disease-specific instrument is available
BACKGROUND: There is a pressing need to improve the accuracy of rare disease clinical study endpoints. Neutral theory, first described here, can be used to assess the accuracy of endpoints and improve their selection in rare disease clinical studies, reducing the risk of patient misclassification. M...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199426/ https://www.ncbi.nlm.nih.gov/pubmed/37210484 http://dx.doi.org/10.1186/s12874-023-01947-z |