CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation

Unbalanced protein homeostasis (proteostasis) networks are frequently linked to tumorigenesis, making cancer cells more susceptible to treatments that target proteostasis regulators. Proteasome inhibition is the first licensed proteostasis-targeting therapeutic strategy, and has been proven effectiv...

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Detalles Bibliográficos
Autores principales: Cheng, Jian, Zhang, Guizhong, Deng, Tian, Liu, Zhao, Zhang, Mengqi, Zhang, Pengchao, Adeshakin, Funmilayo O., Niu, Xiangyun, Yan, Dehong, Wan, Xiaochun, Yu, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199885/
https://www.ncbi.nlm.nih.gov/pubmed/37210387
http://dx.doi.org/10.1038/s41419-023-05858-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199885/
https://www.ncbi.nlm.nih.gov/pubmed/37210387
http://dx.doi.org/10.1038/s41419-023-05858-1

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