Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss

SMARCA4 (BRG1) and SMARCA2 (BRM) are the two paralogous ATPases of the SWI/SNF chromatin remodeling complexes frequently inactivated in cancers. Cells deficient in either ATPase have been shown to depend on the remaining counterpart for survival. Contrary to this paralog synthetic lethality, concomi...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Xianbing, Fu, Zheng, Chen, Shary Y., Ong, Dionzie, Aceto, Giulio, Ho, Rebecca, Steinberger, Jutta, Monast, Anie, Pilon, Virginie, Li, Eunice, Ta, Monica, Ching, Kyle, Adams, Bianca N., Negri, Gian L., Choiniere, Luc, Fu, Lili, Pavlakis, Kitty, Pirrotte, Patrick, Avizonis, Daina Z., Trent, Jeffrey, Weissman, Bernard E., Klein Geltink, Ramon I., Morin, Gregg B., Park, Morag, Huntsman, David G., Foulkes, William D., Wang, Yemin, Huang, Sidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199906/
https://www.ncbi.nlm.nih.gov/pubmed/37210563
http://dx.doi.org/10.1038/s41467-023-38594-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199906/
https://www.ncbi.nlm.nih.gov/pubmed/37210563
http://dx.doi.org/10.1038/s41467-023-38594-3

Ejemplares similares