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Inhibition of DAMP actions in the tumoral microenvironment using lactoferrin-glycyrrhizin conjugate for glioblastoma therapy

BACKGROUND: High-mobility group box-1 (HMGB1) released from the tumor microenvironment plays a pivotal role in the tumor progression. HMGB1 serves as a damaged-associated molecular pattern (DAMP) that induces tumor angiogenesis and its development. Glycyrrhizin (GL) is an effective intracellular ant...

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Detalles Bibliográficos
Autores principales: Kim, Hyung Shik, Park, Seok Chan, Kim, Hae Jin, Lee, Dong Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200060/
https://www.ncbi.nlm.nih.gov/pubmed/37210579
http://dx.doi.org/10.1186/s40824-023-00391-w