Attenuation of Age-Related Hearing Impairment in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice Treated with Fatty Acid Synthase Inhibitor CMS121

In the senescence-accelerated mouse prone 8 (SAMP8) mouse model, oxidative stress leads to premature senescence and age-related hearing impairment (ARHI). CMS121 inhibits oxytosis/ferroptosis by targeting fatty acid synthase. The aim of our study was to determine whether CMS121 is protective against...

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Detalles Bibliográficos
Autores principales: Pham, Tammy B., Boussaty, Ely Cheikh, Currais, Antonio, Maher, Pamela, Schubert, David R., Manor, Uri, Friedman, Rick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200781/
https://www.ncbi.nlm.nih.gov/pubmed/37097512
http://dx.doi.org/10.1007/s12031-023-02119-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200781/
https://www.ncbi.nlm.nih.gov/pubmed/37097512
http://dx.doi.org/10.1007/s12031-023-02119-w

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